Mechanism of action of sedating antihistamines
Antihistamines are valuable in treating skin disorders mediated by histamine. These are primarily used for the symptomatic relief of allergic reactions, such as urticaria and angioedema. Histamine is distributed widely in the animal kingdom and is found in venonis, noxious secretions, bacteria and plants. Its main formation and storage occurs in mast cells but it is also found inepidermal, gastric mucosal cells, neurons within the central nervous system and in rapidly growing tissues.
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