Comparison of non sedating antihistamines


01-Jan-2016 01:47

It is important to note that impaired motor activity and fatigue can also be associated with antihistamine use, and this should be considered when selecting the appropriate AR medication.In patients previously sensitized to specific aeroallergens, subsequent exposure induces an immunoglobulin E–mediated biochemical cascade resulting in mast cell/basophil degranulation and release of inflammatory mediators.AR can be associated with comorbidities, such as asthma, sinusitis, otitis media, and sleep apnea.Quality-of-life issues associated with AR include sleep disturbance, irritability, depression, productivity loss, slowed psychomotor response times, impaired learning and decision making, and fatigue.AR is characterized by 1 or more of the following symptoms: nasal congestion, rhinorrhea, sneezing, and itching.Ophthalmic symptoms include red, itching, and tearing eyes.However, this varies even among second-generation options.Because pharmacists are often asked to make OTC recommendations for AR relief, they must be aware of the prevalence, etiologies, and manifestations of AR, and approaches to its treatment.

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While an individual’s response to allergens varies, OTC therapies can offer an effective initial approach to treatment, should allergen avoidance be difficult or impractical.

PHARMACOLOGY OF ANTIHISTAMINES Antihistamines used to treat AR are competitive antagonists for histamine-1 (H Both first- and second-generation antihistamines alleviate AR symptoms or other upper respiratory allergies.



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