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02-Oct-2016 16:40

Tetracaine, epinephrine [adrenalin], and cocaine [TAC] versus lidocaine, epinephrine, and tetracaine [LET] for anesthesia of lacerations in children. The use of this formulation can reduce patient exposure to cocaine and can reduce costs and security risks for the institution.One institution gives a formulation for this compound as follows: -lace powdered ingredients in graduated cylinder and add water to 100 m L.Beyond use dates are used for compounded preparations and are generally in days or months.The major problem for pharmacists is that the stability of compounded formulations often is not known.

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It was described as a replacement for the problematic, traditional, cocaine-containing TAC solution by Schilling et al in 1995 (Schilling CG, Bank DE, Borchert BA, Klatzko MD, Uden DL. no statistical difference between TAC and LET in adequacy of anesthesia before suturing or in duration of anesthesia during suturing."This result led them to conclude that LET could replace TAC effectively in the emergency room for use while suturing uncomplicated lacerations.

Also, If the compounded formulation is an official monograph in the USP/NF, the beyond use date given in the monograph can be used provided the procedure in the monograph was followed.



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